Describing Wearing Off Wearing Off
Off-time' is when a PD patient's levodopa medication is no longer working. The on-off phenomenon refers to sudden, sometimes unpredictable changes in a. SINEMET improves overall therapeutic response as compared to levodopa. the "on-off" phenomenon, dizziness, somnolence including very rarely excessive. Sinemet CR4 in patients with on-off phenomenon, both preparations led to a reduction in dose-dependent motor fluctua- tions and there was no major.
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